Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma.

BMC Cancer · 2012 · PMC3518100 · PMID 23153310

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ESLI is a potential marker for aggressive PTMC Box plot analysis revealed an increasing trend of Ep-ICD cytoplasm, Ep-ICD nucleus, loss of membranous EpEx as well as ESLI with lymph node metastasis (Figure 2 A and B) which adds credence to our hypothesis that aggressive behavior in PTMC is characterized by loss of surface EpCAM and accumulation of its intracellular domain Ep-ICD.

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