Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

J Biol Chem · 2012 · PMC3522295 · PMID 23105109

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highly significantno p-value reported

Unexpectedly, we observed a highly significant reduction in both MEK and ERK phosphorylation after knockdown of USP15, but not USP4, which was most obvious in serum-starved cells.

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