Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.

Highly significant associations between SNPs located in eQTLs and gene expression in various tissues have been established (such SNPs are referred to as expression SNPs, or eSNPs) [ 30 - 32 ].

also in 132,142 other papers

When testing for the main effect of each SNP, both show non-significant p-values: 1.5 × 10 -5 (rs1130199) and the marginally significant p-values 1.3 × 10 -7 (rs4253764). rs4253764 is located in an intron of PPARA (peroxisome proliferator-activated receptor alpha), while rs1130199 is in an exon near the 3' region of the CDC6 (cell division cycle) gene.

also in 26,082 other papers