Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight.

This produced just one highly significant cluster in the dorsomedial prefrontal cortex (left superior frontal gyrus, BA9; p = .0006 adjusted; see Figure 2 .

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An interaction indicative of relatively lower activity during mental illness trait self-evaluation in schizophrenia was of borderline significance ( p < 0.0059) in one area: right inferior parietal lobule (BA40); peak Talairach coordinates, 47, -33, 37 (see Figure 3 ).

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More lateral and dorsal frontal regions showed relative increases in activation (also self processing areas, see [ 28 ]) in the patient group and a left middle temporal region which failed to reach significance at the cluster level, perhaps representing compensation strategies.

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