Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

However, the rearing activity was increased in heterozygous mice at 2–4 months of age whereas homozygous mice displayed decreased rearing activity at 8 months but both of these trends failed to reach significance; at 12 months of age homozygous mice did not rear at all ( Fig. 2C ).

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The resting membrane potential (RMP) of the MSNs were somewhat more depolarized in the zQ175 mice, although this was a modest and quite variable phenomenon of borderline significance ( Fig. 4a ).

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While this was not significant (One-way ANOVA) when averaging the mean mEPSC frequency value obtained from each neuron recorded per group, analysis of the averaged frequency distribution curves (D'Agostino and Pearson omnibus normality test to test for Gaussian distribution, followed by one sample t-test) were highly significant ( Table 1 ).

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