Genotype-phenotype associations in neurofibromatosis type 1 (NF1): an increased risk of tumor complications in patients with NF1 splice-site mutations?

Hum Genomics · 2012 · PMC3528442 · PMID 23244495

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 1.8 × 10 −27actually significant

The results of this analysis, following removal of outliers, revealed a highly significant effect of the mutation type (specifically splice-site mutations) on the number of CALs, both with 1 to 5 CALs ( p = 1.8 × 10 −27 ) and 6 to 99 CALs ( p = 8.5 × 10 −43 ), as well as for skin freckling ( p = 0.028) and neoplasms ( p = 0.006).

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