Use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release.

Coefficients with t values of effects above the Bonferroni line are designated as significant coefficients coefficients with t values of effects between Bonferroni line and t limit line are termed as coefficients likely to be significant; coefficients with t values of effects below the t limit line are statistically insignificant coefficients [ 20 ].

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