Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci.

These results indicate that there is no detectable relationship between the highly significant susceptibility loci identified by GWAS and the defective release of TNF downstream of TLR activation, with the possible exception of NOD2 , suggesting these could be independent events that coincide in patients with CD.

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