borderline significanceP = 2.00 × 10 −03
Among the 13 age-related metabolites found in the KORA study, 11 metabolites were well replicated in the TwinsUK sample, with P < 0.004 for the significance level after adjustment for multiple testing with the Bonferroni correction method ( Table 2 ), and the effect direction was the same as in the discovery sample (except for one metabolite, PC ae C36:1), with borderline significance in the TwinsUK sample ( P = 2.00 × 10 −03 ).