The failure to detect more than borderline significant differences in the growth-delay of tumours treated with fractionated irradiation alone and fractionated irradiation plus Erufosine may at least partially be due to the unexpected high rate of local tumour control rates that were observed in response to fractionated irradiation alone in the combination experiment 1): Only a low rate of local controls (14%) had been observed in the dose-finding experiment in the highest dose-group (5 × 4.5 Gy) and no local controls had been observed in the 5 × 3.5 Gy dose-group.
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Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice.
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