Visualisation of respiratory tumour motion and co-moving isodose lines in the context of respiratory gating, IMRT and flattening-filter-free beams.

While the averaging effect over a number of fractions counteracts the interplay-effect and produces a comparably good PTV coverage in total, the dose difference between single fractions may be significant [24] , [39] ; whether this is biologically equivalent to a treatment plan with identical fractions is uncertain.

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