Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

21 The levels of the liver enzymes aspartate aminotransferase and alanine aminotransferase, as well as the cellular disintegration marker lactate dehydrogenase, increased by TNF administration in the control group in a highly significant manner, as reported earlier. 21 Creatinine levels rather declined after TNF administration, most likely reflecting muscle catabolism ( Figure 5e ).

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