tuberculosis H37Rv mutants for Rv1290c , Rv1891 or Rv3404c presented a highly significant increase in their survival time as compared with mice infected with the parental strain. 460 For instance, the survival time of the mice infected with the mutant in the Rv1290c gene increased from a median of 25 to 62 d. 460 This strong in vivo attenuation for this mutant clearly shows that Rv1290c has an important function in determining the extent of the virulence of M . tuberculosis .
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