Our combined in vitro and in silico analysis culminated with the assignment of probable furin substrates to key signaling and metabolic pathways, molecular networks and biological processes, suggesting directly that furin proteolysis plays a highly significant role in normal development and embryogenesis, and, specifically, in regulating axonal guidance and cardiogenesis, and maintenance of stem cell pluripotency.
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High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.
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