Identification of candidate polymorphisms on stress oxidative and DNA damage repair genes related with clinical outcome in breast cancer patients.

Int J Mol Sci · 2012 · PMC3546704 · PMID 23443115

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0770

boldest claim

The sentences

borderline significancep -value = 0.058so close (0.05 < p ≤ 0.1)

The survival analysis for rs1052133 shows a trend ( p -value = 0.058, borderline significance) with an OS increase of 15.02 months in the patients with genotype CC + CG versus the patients with the GG genotype (CC + CG: 113.00 months [95% CI 103.64 to 122.35 months] vs.

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a trend toward significancep = 0.077so close (0.05 < p ≤ 0.1)

The polymorphisms rs1052133 and rs207454 show a trend toward significance in the OS analysis when the patients were ER+ ( p = 0.077 and p = 0.053, respectively) ( Figure 2A,B ).

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