Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factors.

Notably, the combined action of Ptf1a and Rbpjl induced not only an increase in early secretory enzyme Ptf1a targets such as Cpa1 , Amyl and ChymoB1 [11] , [28] but also a highly significant increase in Prss3 , Cel and Ela1 levels, expressed later during embryonic development ( Fig. 7A ).

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