The sequence structures of human microRNA molecules and their implications.

PLoS One · 2013 · PMC3548844 · PMID 23349828

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highly significantno p-value reported

Hirsh and Fraser [25] revealed a negative and highly significant relationship between the importance of a gene and the evolutionary rate.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.