Long-term outcome of neoadjuvant systemic therapy for locally advanced breast cancer in routine clinical practice.

J Cancer Res Clin Oncol · 2013 · PMC3549406 · PMID 23052698

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

However, excluding from the analyses patients with luminal A or luminal B/HER2-negative tumors (a group of patients with favorable outcome, representing 51.9 % of the entire study population), pCR resulted predictive of better DRFS ( p = 0.028: HR = 0.37, 95 % CI = 0.19–0.72) with a trend toward significance for OS ( p = 0.06; HR = 0.34, 95 % CI = 0.16–0.77) (Fig. 1 a, b).

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