A critical review of the recent literature and selected therapy guidelines since 2006 on the use of lamotrigine in bipolar disorder.

A positive trend for the superiority of LTG monotherapy in the treatment of patients with refractory mood disorder could be shown (post hoc Q differences: LTG versus GBP, Qdiff = 5.33, P = 0.011; LTG versus PLC, Qdiff = 4.76, P = 0.022; and GBP versus PLC, Qdiff = 0.08, P = 0.700). 24 In 2006, Brown et al 25 compared LTG with the combination of olanzapine/fluoxetine (OFC) in the acute treatment of bipolar 1 depression.

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