Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques.

Diabetes · 2013 · PMC3554387 · PMID 23048186

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Diet-sensitive animals showed a highly significant decrease in fasting insulin levels and in insulin secretion during an IVGTT, suggesting improvement in overall insulin sensitivity in these animals persisted well beyond the cessation of drug treatment.

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