Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study.

12 Interestingly, while no analgesic effect in the 72-hour study assessed by pressure pain tolerance was demonstrated, a highly significant potentiating effect on the CPM system was seen during opioid treatment, with no significant differences between fentanyl- and buprenorphine-treated subjects.

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