Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH.

3 Results Using the well-characterised CFH polyclonal antibody A312 (Quidel, San Diego, CA, USA) for immunoblotting a large and highly significant reduction in CFH was observed in Crry −/− hippocampus compared to controls ( Fig. 1 a).

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