In PC12-TrkA cells, rich in TrkA but lacking L1CAM, long-term treatment with the recombinant protein induced highly significant, dose-dependent neurite outgrowth responses accompanied by an increase in the percentage of cells exhibiting neurites longer than 10 μm (indicated by the numbers drawn in red over the histograms), appreciable already at 1 ng/mL and reaching considerable levels at 100 ng/mL ( Fig. 4 a, upper line; Fig. 4 b, left).
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L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells.
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