The canonical pathway “aryl hydrocarbon receptor signaling” was most significantly associated with the overlap of gene datasets between asthma and COPD, followed by multiple canonical pathways that showed highly significant associations such as the “role of cytokines in mediating communication between immune cells,” “glucocorticoid receptor signaling,” “IL-12 signaling and production in macrophages,” and “hepatic frosts/hepatic stellate cell activation” pathways ( Table 7 ).
1
—
—