When the brains were removed and examined, we found a marked and highly significant reduction in: (i) amyloid plaque load; (ii) the numbers of activated microglial cells; and (iii) the amount of oxidative damage (i.e. 8-oxo-guaninine staining).
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A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.
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