The 3D organization of the yeast genome correlates with co-expression and reflects functional relations between genes.

In the “response to stress” genes, the enrichment of contacts is also highly significant (number of genes = 561, ratio = 1.43 and p-value = 2×10 −3 ).

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Moreover, while experimental biases may be significant when the interactions of a single locus are analysed, in the present study we focus on of linkage properties of large groups of genomic loci and any such effects are expected to average out.

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