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When does NICE recommend the use of health technologies within a programme of evidence development? : a systematic review of NICE guidance.

Pharmacoeconomics · 2013 · PMC3561612 · PMID 23329429

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possibly significantno p-value reported
In both of these cases, the implementation of routine use of the technologies in the NHS could have required substantial infrastructure or training requirements and possibly significant irreversible costs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.