Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.

In our view, the second possibility is more likely since the expression of fibulin-2 representing a marker of fibrogenic portal fibroblasts is highly significant upregulated in FHL2 deficient mice when subjected to CCl 4 challenge (Figure 6 A) , while the expression of GFAP correlating with HSC numbers is the same in FHL2 deficient and control animals under these conditions (Figure 6 B).

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