These data support the notion that inflammasome activation does not occur when the bacteria are confined to intact phagosomes, whereas even the partial disruption of the phagosomal membranes, as executed by Δ pdpC , leads to highly significant, but intermediate levels inflammasome-activating cytosolic signaling.
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The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection.
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