RNA polymerase II mutations conferring defects in poly(A) site cleavage and termination in Saccharomyces cerevisiae.

A smaller—but possibly significant—decrease in the ratio of downstream:uncleaved RNA was noted for three additional mutant strains ( Figure 4D ).

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For one mutant strain, N206Y/V225E/R605G, we observed a highly significant decrease in the ratio.

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