Combined primary tumor and extracranial metastasis status as constituent factor of prognostic indices for predicting the overall survival in patients with brain metastases.

Although the difference of median OS time between the groups of one controlled and none controlled was relatively smaller than that of between the groups of both controlled and one controlled, multivariate analysis consistently showed an increasing trend of hazard ratio among three groups of both controlled, one controlled, and none controlled (1, 1.825, and 2.534, respectively, P < 0.001) ( Table 3 ).

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