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Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.

Br J Anaesth · 2013 · PMC3570068 · PMID 23381720

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Melatonin treatment increased the ATP:O ratio with glutamate/malate but just failed to reach significance with succinate (Fig. 5 b ).

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