A significant increase in DNA damage detected by the Comet assay in leukocytes was denoted for GSTP1 Ile/Val or Val/Val individuals from the exposed group relative to those with GSTP1 Ile/Ile (p ≤ 0.05), especially in younger subjects (p ≤ 0.01), and a nonsignificant trend for interaction with CYP2E1 polymorphism was found.
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Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining.
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