Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy.

The resulting difference between treatment groups for the mean change in visual acuity of individual eyes from baseline of RHODOS to the RHODOS–OFU study visit was highly significant, logMAR −0.228 (11 letters; P = 0.0011; Table 2 ), in favour of the idebenone group for patients carrying one of the three primary mitochondrial DNA mutations and logMAR −0.283 (14 letters, P = 0.0002) for patients carrying either the m.11778G>A or m.3460G>A mutation.

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