Our microarray analyses revealed a substantial and highly significant overlap between gene expression changes elicited by EVI1 expression and etoposide treatment, suggesting that EVI1 overexpressing cells may be partially pre-adapted to the exposure to cytotoxic drugs.
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EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.
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