Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice.

PLoS One · 2013 · PMC3574143 · PMID 23457539

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closest p · 1.8× alpha

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marginally non-significantP = 0.09so close (0.05 < p ≤ 0.1)

There was marginally non-significant variation among genotypes in birth mass (F 2,53 = 2.54; P = 0.09), with a trend towards lower birth mass in pups homozygous for the PAPP-A2 deletion ( Table 4 ).

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highly significantno p-value reported

Consistent with the highly significant effect on 10 week body mass and tail length, PAPP-A2 deletion had a significant effect on mandible dimensions and the lengths of the skull, humerus, femur, tibia, pelvic girdle, and tail bone ( Table 4 ); the effect on the length of the ulna/radius was marginally non-significant (F 2,60 = 2.71; P = 0.08).

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