Barely Significant
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Protective effect of caffeine against high sugar-induced transcription of microRNAs and consequent gene silencing: a study using lenses of galactosemic mice.

Mol Vis · 2013 · PMC3580991 · PMID 23441122

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highly significantno p-value reported
Interestingly, caffeine has a highly significant effect of decreasing the risk of the development of type 2 diabetes [ 83 - 85 ], a highly prevalent aging disease whose incidence is projected to undergo a substantial increase in the coming years [ 86 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.