Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy.

This observation consistent with less pronounced nitrated protein accumulation in diabetic CHOP −/− mice is highly significant because oxidative-nitrative stress is one of the key mechanisms underlying MNCV and SNCV deficits, neurovascular dysfunction, and small sensor fiber neuropathy in diabetes ( 6 – 9 , 12 , 15 , 39 ).

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