highly significantp < 0.0001
The minor allele frequency of rs2607474 in the methylated group was significantly lower than that in the unmethylated group (p = 0.0004, setting α = 0.05, 1-βpower = 0.946) and the frequency of the GG homozygote was significantly higher in the methylated group than in the unmethylated group (p = 0.013). Risk associated with rs2607474 GG homozygote for DAPK and CDH1 methylation Overall, rs2607474 GG homozygote conferred a highly significant increased risk for the development of DAPK methylation (OR, 2.43; 95%CI, 1.60-3.69; p < 0.0001; Table 4 ).