Repeat prostate biopsy strategies after initial negative biopsy: meta-regression comparing cancer detection of transperineal, transrectal saturation and MRI guided biopsy.

After accounting for differences due to strategy, mean age and mean PSA in the meta-regression analysis, the amount of residual heterogeneity between studies was calculated to be 76.0, which is highly significant at the 5% level (QE = 176.8, p<0.0001).

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