Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma.

For all 3 markers, the difference in antigen expression between glioblastoma and anaplastic astrocytoma was highly significant ( Table II ). mTOR activity and proliferation Similar to hypoxia-inducible proteins, intertumor heterogeneity of proliferation and mTOR activity was pronounced. mTOR activity (as assessed by the abundance of p-rpS6) was significantly higher in glioblastomas compared to anaplastic astrocytomas, while there was only a trend for higher proliferation (Ki67) in these tumors ( Table II ).

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