A metabolic prototype for eliminating tryptophan from the genetic code.

Sci Rep · 2013 · PMC3584311 · PMID 23447021

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highly significantno p-value reported

This result is highly significant as it provides experimental evidence for the feasibility of genetic code reassignment through natural selection as an adaptive response to pressure for miscoding enforced metabolically.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.