Promoter hypermethylation of estrogen receptor alpha gene is correlated to estrogen receptor negativity in Iranian patients with sporadic breast cancer.

Cell J · 2012 · PMC3584424 · PMID 23508069

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an increasing trendno p-value reported

But in one study, the comparison of DCIS (Ductal Carcinoma In Situ), invasive ductal carcinoma and metastatic lesions showed an increasing trend in ERα methylation with malignant progression ( 25 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.