Array-based identification of common DNA methylation alterations in ulcerative colitis.

Of note, we found a borderline significant enrichment of genes with protein kinase C-like domains (RASGRP1, CDC42BPB and PRKCB; EASE score, 0.14; Fisher’s exact test P=0.016).

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For hypermethylation, this analysis revealed a highly significant overrepresentation of genes encoding transcriptional factors (GOterm 0003700, n=49, fold enrichment, 1.86; EASE score, 1.14×10 −5 ), in particular, transcriptional factors with homeobox domains (Interpro IPR001356, n=25, fold enrichment, 3.32; EASE score, 1.9×10 −7 ).

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