Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study.

51 However, after adjusting for intakes of Ca and potassium, all these inverse associations not only disappeared but also became positive associations, which were significant for total stroke in women with an HR (95% CI) of 1.81 (1.12 to 2.94) for the highest quintile intake versus the lowest (p for trend, 0.015) and of borderline significance for ischaemic stroke in women (p for trend, 0.081).

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It is worth noting that, at borderline significance, high Ca intake was associated with a reduced risk of death due to colorectal cancer, whereas Mg intake was associated with an increased risk of gastric cancer mortality, particularly among those with a Ca/Mg ratio ≤1.7 (p for interaction, 0.05).

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