marginal significanceP =0.11
The mean level of H3K27 trimethylation (associated with gene repression) was significantly decreased in the autism compared with control samples ( P = 0.02), and the mean level of histone H3K4 trimethylation (associated with gene activation) in the EN-2 promoter was increased in autism relative to the matched control samples with marginal significance ( P =0.11).