Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis.

For this list of 1409 DETs unique to the ASD GI ileal biopsies, the Diseases and Disorders category returned highly significant associations with: (1) gastrointestinal disease [217 genes; p = 1.4×10 −08 ] including inflammatory bowel disease [42 genes; p = 3.2×10 −05 ] and colitis [25 genes; p = 8,8×10 −04 ] and (2) inflammatory response [198 genes; p = 3.8×10 −07 ] including inflammation of organ [88 genes; p = 3.8×10 −7 ], antibody response [27 genes; p = 2.1×10 −6 ] and activation of leukocytes [74 genes; p = 4.9×10 −6 ].

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