Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells.

In G 0 /G 1 -phase cells, HR mediated by contact between homologous chromosomes would allow error-free repair of the relatively small number of DSBs that arise in genes, which could be a highly significant mechanism that prevents mutations in coding regions of DNA that are critical for cell viability and function.

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We suggest that such mechanisms may be significant for genome stability and human health.

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