highly significantP < 3.7 × 10 − 110
Therefore, we calculated the statistical probabilities of two-way overlap between exosome and CP190, BEAF-32 or CTCF sites by hypergeometric tests considering only active TSSs of all annotated gene isoforms and indeed observed highly significant overlap over expectation ( P < 3.7 × 10 − 110 for each comparison).