Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.

J Transl Med · 2013 · PMC3599052 · PMID 23433424

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a favorable trendno p-value reported

With IL2 support, 1 st gen dTc had a significant effect (p=0.05) while 2 nd gen dTc (p=0.13) demonstrated a favorable trend (Figure 5 B). 1 st gen dTc may be more reliant on IL2 than 2 nd gen dTc because the presence of the co-stimulatory signal through the CD28 portion of the construct may reduce the dependence of 2 nd gen dTc on cytokines such as IL2.

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